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Expert Rev Endocrinol Metab ; 16(3): 147-153, 2021 05.
Article Dans Anglais | MEDLINE | ID: covidwho-1165207

Résumé

Objectives: Changes in hematological parameters are becoming evident as important early markers of COVID-19. Type 2 Diabetes Mellitus (T2DM) has been shown to be associated with increased severity of COVID-19. In this study, we aim to explore the various hematological variables in COVID-19 positive patients with T2DM, so as to act early and improve patient outcomes.Methods: Medical e-records of seventy adult patients with T2DM who were COVID-19 positive have been analyzed in this retrospective cohort study. Demographic, clinical and laboratory parameters for these patients were examined.Results: Of the seventy patients with T2DM, 48.88% had poorly controlled diabetes. 70.69% were pyrexial, 56.25% were tachycardic and 38.58% were asymptomatic on presentation. Amongst the hematological parameters, anemia was seen in 10% of males and 15.38% of females. 20% had a high red-blood-cell-distribution-width (RDW). 7.27% had thrombocytosis and 3.64% had thrombocytopenia. 73.3% had a high platelet-distribution-width (PDW) and 44.44% had an increased mean-platelet-volume (MPV). 16.36% were neutropenic and 16.67% had lymphocytopenia.Conclusion: Diabetic COVID-19 positive patients have been shown to have prominent manifestations of the hemopoietic-system with varied hematological profiles. Recognizing the implications of these variables early in primary-care, can help clinicians aid management decisions and dictate early referral to secondary-care services, to help improve prognosis.


Sujets)
COVID-19/sang , Diabète de type 2/sang , Hémopathies/sang , Soins de santé primaires/tendances , Adulte , Anémie/sang , Anémie/diagnostic , Anémie/épidémiologie , Marqueurs biologiques/sang , COVID-19/diagnostic , COVID-19/épidémiologie , Études de cohortes , Diabète de type 2/diagnostic , Diabète de type 2/épidémiologie , Index érythrocytaires/physiologie , Femelle , Hémopathies/diagnostic , Hémopathies/épidémiologie , Humains , Mâle , Volume plaquettaire moyen/méthodes , Volume plaquettaire moyen/tendances , Adulte d'âge moyen , Numération des plaquettes/méthodes , Numération des plaquettes/tendances , Soins de santé primaires/méthodes , Études rétrospectives , Thrombopénie/sang , Thrombopénie/diagnostic , Thrombopénie/épidémiologie
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